Our initial focus is on eosinophilic gastrointestinal diseases (EGIDs), a group of chronic inflammatory diseases characterized by persistent gastrointestinal symptoms as well as elevated mast cells and eosinophils in the esophagus, stomach, duodenum and/or colon.
We strive to understand the needs of patients and are committed to collaborating with patients, advocacy groups, and physicians to incorporate their perspectives and needs into our development programs.
Eosinophilic Gastritis and/or Eosinophilic Duodenitis (EG/EoD)
Eosinophilic gastritis (EG) and/or eosinophilic duodenitis (EoD, previously referred to as eosinophilic gastroenteritis or EGE) are chronic, inflammatory diseases characterized by high levels of mast cells and eosinophils (two types of immune system cells) in the stomach and/or the duodenum. Common symptoms of these diseases include chronic abdominal pain, nausea, bloating, loss of appetite, early satiety, abdominal cramping, vomiting and diarrhea. Because many of these symptoms are non-specific, it can often take a long time for patients to be properly diagnosed with EG/EoD. It is estimated that about 50,000 patients have been diagnosed with EG/EoD in the United States, but recent evidence indicates that EG/EoD is highly underdiagnosed.
There are no approved treatments for EG/EoD, but diet modification and steroids can temporarily relieve symptoms.
Eosinophilic Esophagitis (EoE)
Eosinophilic esophagitis (EoE) is a chronic, inflammatory disease characterized by high levels of mast cells and eosinophils (two types of immune system cells) in the esophagus (muscular tube connecting the mouth to the stomach). Common symptoms include difficulty swallowing, food impaction (food becoming lodged in the esophagus when trying to swallow), nausea, vomiting, and abdominal pain. It is estimated that approximately 180,000 people in the United States have been diagnosed with EoE. While there are no FDA-approved treatments for EoE, esophageal dilation, diet modification, stomach acid suppressors and topical steroids can temporarily relieve symptoms.
In an effort to provide patients and their families with access to valuable resources for EGIDs, we have compiled the following links. These links will take you away from the Allakos website, but will connect you with other sources of information that may be useful.